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Recombinant SMYD2 protein
Recombinant SMYD2 protein
- 中文名称：
- Recombinant SMYD2 protein
- 英文名称：
- Recombinant SMYD2 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59718
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- The recombinant protein is >90% pure by SDS-PAGE.
- 产品形式：
- Full length recombinant SMYD2 protein expressed in Sf9 cells and is supplied in 25mM Hepes pH7.5, 300mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant SMYD2 protein (accession number NP_064582.2) was expressed in Sf9 cells and contains an N-terminal DYKDDDDK-Tag with a molecular weight of 50.7 kDa. The recombinant protein is >90% pure by SDS-PAGE. It is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: SMYD2 (SET and MYND domain containing protein 2) is a lysine methyltransferase that methylates both histones and non-histone proteins. Specifically, SMYD2 methylates histone H3 Lys4 (H3K4me1) and dimethylates histone H3 Lys36 (H3K36me2). SMYD2 also exhibits methyltransferase activity toward non-histone proteins such as p53 and pRb. SMYD2 monomethylates Lys370 of p53, leading to decreased DNA-binding activity and subsequent inhibition of p53-mediated transcriptional regulation. SMYD2 also monomethylates Lys860 of pRb.
