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Recombinant HDAC9 (604-1066) protein
Recombinant HDAC9 (604-1066) protein
- 中文名称：
- Recombinant HDAC9 (604-1066) protein
- 英文名称：
- Recombinant HDAC9 (604-1066) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59742
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- The purity of HDAC9 protein is >80% by SDS-PAGE.
- 产品形式：
- Recombinant HDAC9 (604-1066) protein is supplied at a concentration of 0.25ug/ul in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant HDAC9 (604-1066) protein includes amino acids 604-1066 of human HDAC9 protein (accession number NP_848510.1); it was expressed in Sf9 cells and contains an C-terminal DYKDDDDK-Tag with a molecular weight of 60.3 kDa. The purity of HDAC9 protein is >80% by SDS-PAGE. It is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: HDAC9 (Histone Deacetylase 9) is a member of the class IIa mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-epsilon-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue.In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11).In humans, HDAC9 is expressed in a wide variety of tissues. This gene is orthologous to the Xenopus and mouse MITR genes. HDAC9 represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDAC1 and/or HDAC3. HDAC9 may play a role in hematopoiesis. It seems to inhibit skeletal myogenesis and to be involved in heart development. HDAC9 protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
