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Recombinant HDAC8 protein, His-Tag
Recombinant HDAC8 protein, His-Tag
- 中文名称：
- Recombinant HDAC8 protein, His-Tag
- 英文名称：
- Recombinant HDAC8 protein, His-Tag
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59754
- 规格：
- 0.05 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- The HDAC8 protein, His-Tag is >90% pure by SDS-PAGE.
- 产品形式：
- Recombinant full length HDAC8 protein, His-Tag is supplied in 25mM Tris pH8.0, 300mM NaCl, 20% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant human HDAC8 protein, His-Tag was expressed in a baculovirus expression system as the full-length protein (accession number NP_060956.1) with a C-terminal 6xHis-tag. The molecular weight of the protein is 43.8 kDa. The HDAC8 protein, His-Tag is >90% pure by SDS-PAGE. It is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: HDAC8 (Histone Deacetylase 8) is a member of the class I mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-epsilon-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). HDAC8 catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. It also is involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. HDAC8 may play a role in smooth muscle cell contractility.
