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Recombinant PTPN1 protein
Recombinant PTPN1 protein
- 中文名称：
- Recombinant PTPN1 protein
- 英文名称：
- Recombinant PTPN1 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60113
- 规格：
- 0.05 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant PTPN1 protein is supplied at a concentration of 0.2ug/ul in 25mM Tris pH8.0, 300mM NaCl, 10% glycerol, 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant PTPN1 protein was expressed in E Coli as the full-length protein (accession number NP_002818.1) with an N-terminal GST-Tag. The molecular weight of the protein is 76.3 kDa. It is suitable for analysis of tyrosine phosphatase activity in vitro as well as for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: PTPN1 (protein tyrosine phosphatase, non-receptor type 1, also known as PTP1B) is a member of the protein tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family have a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation as signaling molecules. Epidermal growth factor receptor (EGFR) and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. PTPN1 acts as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. PTPN1 dephosphorylates epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases.
