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Recombinant VRK1 protein
Recombinant VRK1 protein
- 中文名称：
- Recombinant VRK1 protein
- 英文名称：
- Recombinant VRK1 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60130
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant VRK1 protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: VRK1 (Vaccinia Related Kinase 1), also known as PCH1A, is a serine/threonine kinase. It is involved in Golgi disassembly during the cell cycle, by which following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation. VRK1 acts by mediating phosphorylation of downstream target protein. It can phosphorylate Thr-18 of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. It phosphorylates BANF1, thus disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. VRK1 also phosphorylates casein and histone H3, as well as ATF2 which activates its transcriptional activity.
