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Recombinant NgTet1 (1-321) protein
Recombinant NgTet1 (1-321) protein
- 中文名称：
- Recombinant NgTet1 (1-321) protein
- 英文名称：
- Recombinant NgTet1 (1-321) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60157
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant NgTet1 protein is supplied in 25mM Tris pH8.0, 300mM NaCl, 10% glycerol, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant NgTet1 protein was expressed in E Coli as the full-length protein (accession number XP_002667965.1) with an N-terminal 6xHis-tag. The molecular weight of NgTet1 is 38.7 kDa. It is suitable for use in cytosine oxygenase assays, 5-mC sequencing, enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: Ten Eleven Translocation (TET) family proteins are cytosine oxygenases that catalyze the conversion of 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). 5-hmC can be further oxidized into 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC) by TET proteins. Methylation at the C5 position of cytosine is an epigenetic modification of the mammalian genome that plays an important role in transcriptional regulation. TET proteins are responsible for iinitiating the enzymatic deamination process leading to cytosine demethylation. The Tet family of dioxygenases is widely distributed across the tree of life, including in the heteroloboseanamoeboflagellate Naegleria gruberi. NgTet1 (Naegleria Tet-like protein) is a homologue of mammalian Tet proteins. Like mammalian Tet proteins, NgTet1 acts on 5-mC and generates 5-hmC, 5-fC and 5-caC.
