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Recombinant KAT1/HAT1 protein
Recombinant KAT1/HAT1 protein
- 中文名称：
- Recombinant KAT1/HAT1 protein
- 英文名称：
- Recombinant KAT1/HAT1 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60201
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant KAT1/HAT1 protein supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Full-length KAT1/HAT1 protein (accession number NP_003633.2) was expressed in a baculovirus expression system with an N-terminal DYKDDDDK tag. The molecular weight of KAT1/HAT1 is 50.8 kDa. Recombinant KAT1/HAT1 protein is suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: KAT1/HAT1 (Histone Acetyltransferase 1), is a type B histone acetyltransferase that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. It acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). It has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. HAT1 may be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. It may also play a role in DNA repair in response to free radical damage.
