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Recombinant Estrogen Receptor a protein
Recombinant Estrogen Receptor a protein
- 中文名称：
- Recombinant Estrogen Receptor a protein
- 英文名称：
- Recombinant Estrogen Receptor a protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60203
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant Estrogen Receptor-alpha protein is supplied in 25mMHEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant Estrogen Receptor-alpha protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_000116.2) with an N-terminal DYKDDDDK tag. The molecular weight of the protein is 67.5 kDa.
Background: Estrogen Receptor-alpha protein, also called as ESRA or ER-alpha, is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. ER-alpha can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. It also mediates membrane-initiated estrogen signaling involving various kinase cascades.
