-
Recombinant JAK2 (532-1132) protein
Recombinant JAK2 (532-1132) protein
- 中文名称：
- Recombinant JAK2 (532-1132) protein
- 英文名称：
- Recombinant JAK2 (532-1132) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60212
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant JAK2 (532-1132) protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant JAK2 (532-1132) protein that includes amino acids 532-1132 of human JAK2 protein (accession number NP_004963.1) was expressed in a baculovirus expression system and contains an N-terminal DYKDDDDK-Tag. The molecular weight of the protein is 71 kDa. Recombinant JAK2 (532-1132) protein is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: JAK2 (Janus Kinase 2), also known as Tyrosine-Protein Kinase JAK2 or JTK10, is a non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. In the cytoplasm, JAK2 plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO);or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, JAK2 can phosphorylate specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Then it can subsequently phosphorylate the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. JAK2 signaling is implicated in diverse biological processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and alteration of heterochromatin.
