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Recombinant NUAK1 (ARK5) protein
Recombinant NUAK1 (ARK5) protein
- 中文名称：
- Recombinant NUAK1 (ARK5) protein
- 英文名称：
- Recombinant NUAK1 (ARK5) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60221
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant NUAK1/ARK5 protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant NUAK1/ARK5 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_055655.1) with a C-terminal DYKDDDDK tag. The molecular weight of the protein is 76 kDa.
Background: NUAK1, also known as ARK5, is the fifth member of the AMPK catalytic subunit family. It is a serine/ threonine-protein kinase that are activated by phosphorylation at its Ser600 by Akt, which has been reported to be a key player in tumor malignancy. The activated NUAK1 involves in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation an tumor progression, such as it acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1,and Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Which also involves in DNA damage response by phosphorylating p53/ TP53 at 'Ser-15' and 'Ser-392', and it is a sensitive indicator of cellular energy status and have been found to promote tumor cell survival during nutrient starvation.
