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Recombinant SETD1B-SET complex
Recombinant SETD1B-SET complex
- 中文名称：
- Recombinant SETD1B-SET complex
- 英文名称：
- Recombinant SETD1B-SET complex
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60223
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant SETD1B-SET Complex is supplied in 25mM HEPESNaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant SETD1B-SET Complex that includes amino acids 1669-1966 of human SETD1B protein (accession number NP_001340274.1) with a N-terminal DYKDDDDK tag and full-length human WDR5 protein (accession number NP_060058.1) without tag and full-length human RBBP5 protein (accession number NP_005048.2) without tag and full-length human ASH2L protein (accession number NP_001098684.1) without tag was expressed in Sf9 cells. The molecular weights of SETD1A-SET, WDR5, RBBP5,ASH2L are 35.7 kDa, 36.6 kDa, 59.2 kDa and 68.7 kDa, respectively. This complex is suitable for use in protein-protein interaction, in vitro transcription assay, binding assays.
Background: SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) is a component of a histone methyltransferase (HMT) complex (contain SETD1B-SET ASH2L, RBBP5, WDR5) that produces mono-, di-, and trimethylated histone H3 at Lys4, but not if the neighboring 'Lys-9' residue is already methylated. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily.
