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Recombinant HIPK2 (1-640) protein
Recombinant HIPK2 (1-640) protein
- 中文名称：
- Recombinant HIPK2 (1-640) protein
- 英文名称：
- Recombinant HIPK2 (1-640) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60233
- 规格：
- 0.05 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant HIPK2 (1-640) protein is supplied in 25mM HEPES-NaOH pH7.5, 500mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: HIPK2 (Homeodomain Interacting Protein Kinase 2) is a conserved serine/threonine kinase that involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. It acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. HIPK2 phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. It inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation), the phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex.
