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Recombinant FYN (2-537) protein
Recombinant FYN (2-537) protein
- 中文名称：
- Recombinant FYN (2-537) protein
- 英文名称：
- Recombinant FYN (2-537) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60239
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant FYN (2-537) protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: FYN (FYN Proto-Oncogene, Src Family Tyrosine Kinase) is a non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/ FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. FYN involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) and regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubuleassociated proteins MAP2 and MAPT. It also promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Disieases associated with FYN include Hepatitis E and Autoimmune Cardiomyopathy
