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Recombinant MAP3K8 (30-397)/COT protein
Recombinant MAP3K8 (30-397)/COT protein
- 中文名称：
- Recombinant MAP3K8 (30-397)/COT protein
- 英文名称：
- Recombinant MAP3K8 (30-397)/COT protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60250
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant MAP3K8/COT (30-397) protein is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8) is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. It also involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells and involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro>, MAP3K8 activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner and leading to up-regulation of IL8 and CCL4 and transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages. Thus MAP3K8 may play a role in the regulation of immunoglobulin production and may also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, MAP3K8 activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF.
