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Irisin: Human, Tagless (Recombinant protein)
Irisin: Human, Tagless (Recombinant protein)
- 中文名称：
- Irisin: Human, Tagless (Recombinant protein)
- 英文名称：
- Irisin: Human, Tagless (Recombinant protein)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60557
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store lyophilized protein at -20 degree C. Aliquot reconstituted protein and store at -80 degree C. Avoid repeated freezing /thawing cycles.
- 货期：
- 6-8周
- 纯度：
- >95%; SDS PAGE to determine purity of the protein
- 产品形式：
- Lyophilized in 1mg/mL in PBS
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Exercise enhances muscular endurance and strength, calories expenditure, and prevents the development of obesity and type 2 diabetes. These effects of exercise cannot be explained solely by the expenditure of calories in muscle. A recent study indicated that a novel hormone, irisin, plays an important role in the increase of total body energy expenditure by exercising muscle. Irisin is a cleaved and secreted fragment of a membrane protein FNDC5. And its circulating concentrations are increased after regular physical activity. Exercise induces the transcriptional regulator PGC-1alpha in the skeletal myocyte, which in turn drives the production of the FNDC5. Animal experiments suggested that irisin, cleaved form FNDC5, activates thermogenic programs in white adipose tissue (“browning"), including mitochondrial biogenesis and the expression of uncoupling protein 1 (UCP1), leading to mitochondrial heat production and energy expenditure. Irisin is highly conserved across species, and exercise also increases circulating irisin concentrations in humans. Therefore, the role of irisin in humans may be that it links physical activity to energy metabolic homeostasis, including weight control.
The recombinant irisin is the extracellular domain of FNDC5 (Asp16 to Thr136). Total 126 AA. Mw: 14kDa (calculated). N-terminal His-tag removed, 5 extra AA left.
