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mDia Phospho-Regulation
mDia Phospho-Regulation
- 中文名称：
- mDia Phospho-Regulation
- 英文名称：
- mDia Phospho-Regulation
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71616
- 规格：
- 1 Kit|2x1 Kit|3x1 Kit|4x1 Kit|5x1 Kit
- 保存建议：
- Store at -20 degree C. Stable for 1 year.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Rabbit polyclonal, affinity-purified antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Formins include several families of proteins that regulate actin cytoskeletal dynamics via two conserved formin homology domains, FH1 and FH2. Formins construct actin-based structures comprising linear, unbranched filaments that are used in stress fibers, actin cables, microspikes, and contractile rings. The diaphanous (Dia) formin subfamily includes mDia1 (Diap1), mDia2 (Diap3), and mDia3 (Diap2). mDia1 protein is activated by Rho leading to ROCK-dependent stress fiber formation and regulation of serum response factor-dependent transcription. mDia2 is activated by Rac or Cdc42, and it nucleates actin polymerization and stabilizes microtubules. Regulation of mDia2 activity may occur through ROCK phosphorylation of Thr-1061 and Ser-1070. mDia3 is activated by Cdc42 and regulates the attachment of microtubules to the kinetochore during mitosis. Aurora B kinase phosphorylates Ser-196 and Thr-882 in vitro, and phosphorylation of Ser -196 increases during mitosis in vivo.
