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KAT2B (PCAF), Active
KAT2B (PCAF), Active
- 中文名称：
- KAT2B (PCAF), Active
- 英文名称：
- KAT2B (PCAF), Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA72995
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Recombinant human KAT2B (PCAF) (431-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: KAT2B (also known as PCAF) is a transcription cofactor with a histone acetyltransferase (HAT) activity. KAT2B protein associates with p300/CBP which is a large nuclear protein that bind to many sequence-specific factors that are involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A (1). KAT2B has histone acetyl transferase activity with core histones and nucleosome core particles indicating that KAT2B plays a direct role in transcriptional regulation (2). PCAF functions as a coordinating factor in the regulation of HIF1A-mediated apoptosis and p53-dependent cell cycle progression.
