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LCMT1, Active
LCMT1, Active
- 中文名称：
- LCMT1, Active
- 英文名称：
- LCMT1, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73011
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Recombinant full-length human LCMT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: Leucine carboxyl methyltransferase 1 (LCMT1) exclusively methylates the carboxyl group of leucine-309 in the catalytic subunit of protein phosphatase 2A (1). LCMT1 is essential for normal progression through mitosis and cell survival. Knocking-down LCMT1 leads to reduced formation of PP2A heterodimers and increased apoptosis (2). LCMT1 also regulates the association of PP2A and its substrate, Tau protein, with plasma membrane in neuroblastoma cells. Decreased level of PP2A methylation is found in Alzheimer disease (3).
