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TFG-TRKA Mutant (TRK-T3), Active
TFG-TRKA Mutant (TRK-T3), Active
- 中文名称：
- TFG-TRKA Mutant (TRK-T3), Active
- 英文名称：
- TFG-TRKA Mutant (TRK-T3), Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73034
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Recombinant human fusion TFG (1-193)-TRKA (399-end) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: TFG-TRKA (TRK-T3) is a chimeric cytoplasmic oncoprotein isolated from a papillary thyroid tumor. This oncoprotein is the consequence of a t (1, 3) translocation juxtaposing the tyrosine kinase domain of the NTRK1 receptor to the N-terminal portion of a protein encoded by TFG (TRK-fused gene), a novel gene first discovered in the rearranged form. TRK-T3 fusion oncoprotein displays a constitutive tyrosine kinase activity resulting in its capability to transform mouse NIH3T3 cells. The TFG portion of TRK-T3 contains a coiled-coil domain most likely responsible for the constitutive, ligand-independent activation of the receptor tyrosine kinase activity through TRK-T3 oligomerization.
