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NDR, Active
NDR, Active
- 中文名称：
- NDR, Active
- 英文名称：
- NDR, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73145
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
- 货期：
- 6-8周
- 纯度：
- >90%
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Full-length recombinant human NDR1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_007271.
Scientific Background: NDR or Nuclear Dbf2-related protein is a serine-threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins (1). Fas and TNF? receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase and key member of the RASSF1A/MST1 signaling cascade (2). NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells and is incorporated into the HIV-1 particles and cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
