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2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)
2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)
- 中文名称：
- 2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)
- 英文名称：
- 2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73324
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|2x0.1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant 2019-nCoV Spike protein S1 (delta69-70, Y453F, D614G)(16-685) was expressed in CHO cells using a C-terminal His-tag. The gene accession number is MN908947.
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2)(1). Upon binding of S1 subunit of Spike protein to the host ACE2, TMPRSS2 cleaves at the S1/S2 boundary or within S2 subunit to facilitate the entry of viral genomes into the host cells. SARS-CoV-2 variant comprising Y453F and delta 69-70 mutations has been detected in human cases in Denmark. Y453F mutation associated with the mink infections has mild positive effect on viral binding to host cell. However, D614G and deltaH69/V70 have been considered to enhance viral transmissibility and infectivity, respectively (3, 4).
