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2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R)
2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R)
- 中文名称：
- 2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R)
- 英文名称：
- 2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73329
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|2x0.1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant 2019-nCoV Spike protein S1 (T19R, G142D, delta157-158, L452R, T478K, D614G, P681R)(16-685) was expressed in CHO cells using a C-terminal His-tag. The gene accession number is MN908947.
Since 2020, the novel coronavirus SARS-CoV-2 has caused respiratory disease (COVID-19) pandemic around the world. The coronavirus spike glycoprotein (S) is a type I transmembrane protein that contains the S1 and S2 subunits and it interacts with the host cell angiotensin-converting enzyme 2 (ACE2) to facilitate viral genome entry (1). The delta variant (B.1.617.2 lineage), first discovered in India, possesses several key mutations that may explain its replacement over the alpha variant. The receptor binding domain (RBD) mutations L452R and T478K lead to increased binding to ACE2 and decreased neutralization potential (2). Mutation D614G increases viral infectivity; mutation P681R in the furin cleavage site promotes the cleavage rate of the S1-S2 making the virus more transmissible and more infectious. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence, and their possible tendency to escape antibody neutralization (3).
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