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CK1 alpha 1, Active
CK1 alpha 1, Active
- 中文名称：
- CK1 alpha 1, Active
- 英文名称：
- CK1 alpha 1, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73374
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Full length recombinant human CK1a1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_001892.
CK1alpha1 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes. CK1alpha1 can regulate Smo cell surface accumulation and activity in response to hedgehog. CK1alpha1 phosphorylate Smo at several sites and phosphorylation-deficient forms of Smo fail to accumulate on the cell surface and are unable to transduce the hedgehog signal (1). CK1alpha1 dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. CK1alpha1 can form complex with MDM2 which then regulates the stability of p53 and E2F-1 transcription factors (2).
