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DGKE, Active
DGKE, Active
- 中文名称：
- DGKE, Active
- 英文名称：
- DGKE, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73412
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant full-length human DGKE was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The DGKE gene accession number is NM_003647.
Diacylglycerol kinase epsilon (DAG kinase epsilon) is the only member of class III diacylglycerol kinase family, which lacks the E-F hand motifs for Ca+ binding but possess a clear selectivity for arachidonoyl-containing species of diacylglycerol (1). DGK epsilon might decrease signals conducted via arachidonoyl-diacylglycerol or promotes the synthesis of phospholipids with certain fatty acids (1). DGK epsilon contributes to Huntington disease pathogenesis and its inhibition might be effect in the therapeutics (2). Also, recessive mutations in DGKE results in unrestricted complement activation in atypical hemolytic-uremic syndrome (3).
