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LRRK1, Active
LRRK1, Active
- 中文名称：
- LRRK1, Active
- 英文名称：
- LRRK1, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73642
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human LRRK1 (622-1610) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The LRRK1 gene accession number is NM_024652.
LRRK1, also called leucine-rich repeat kinase 1, is highly expressed in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. Mutations in LRRK1 corresponding to Parkinson disease-8 -associated mutations found in LRRK2, significantly reduced LRRK1 kinase activity (1). LRRK1 expression in all mouse brain regions examined, with highest expression in olfactory bulb (2). LRRK1 functions as a GDP/GTP-binding protein and its kinase activity is stimulated upon binding of GTP to the ROC domain.
