-
MEKK4, Active
MEKK4, Active
- 中文名称：
- MEKK4, Active
- 英文名称：
- MEKK4, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73657
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human MEKK4 (1203-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The MEKK4 gene accession number is NM_005922.
MEKK4 is one of the MAPKKKs which mediates activation of both p38 and JNK. N-terminal region of MEKK4 contains an autoinhibitory domain that interacts with the C-terminal kinase domain, inhibits kinase activity and prevents interaction with its substrate, MKK6. MEKK4 is activated upon binding of GADD45 by the stress-inducible GADD45 family of proteins (GADD45alpha/beta/gamma). GADD45 binds to the N-terminal region of MEKK4 releasing inhibition of the kinase domain by the autoinhibitory domain (1). MEKK4 is strongly expressed in the developing neuroepithelium and is critical for neural tube closure (2).
