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PKC beta I, Active
PKC beta I, Active
- 中文名称：
- PKC beta I, Active
- 英文名称：
- PKC beta I, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73859
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant full-length human PKCbeta I was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is X06318.
PKCbetaI is a member of the PKC family (phospholipid-dependent serine/threonine kinase) and is highly related to PKCbeta II. Unlike the mature PKCbeta II mRNA and protein, which rapidly increase following acute insulin treatment, the PKCbetaI mRNA and protein levels remain unchanged (1). The stable overexpression of PKCbetaII, but not PKCbetaI, leads to insulin-stimulated glucose uptake into cells. Upon stimulation of B lymphocytes and mast cells, Syk regulates Btk, and Btk selectively regulates enzymatic activity of PKCbetaI. Specific regulation of PKCbetaI by Btk is consistent with the selective association of Btk with PKCbetaI (2).
