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SENP6, Active
SENP6, Active
- 中文名称：
- SENP6, Active
- 英文名称：
- SENP6, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73977
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human SENP6 (637-1112) was expressed in E Coli cells using an N-terminal His tag. The SENP6 gene accession number is NM_015571.
SENP6 is a mammalian SUMO protease that preferentially disassembles conjugated SUMO2/3 chains. It is found in the nucleoplasm and possess a conserved sequence insertion within the catalytic domain which is absent in the catalytic domains of the other SENP family members (1). SENP6 has been shown to be essential for cell proliferation and cell cycle progression with a prominent role during mitosis (2). SENP6 depleted cells exhibit defects in the spindle assembly and metaphase chromosome congression resulting in mitotic problems and cell death. Thus, SENP6 inhibitors have clinical potential against highly proliferative cancer cells (3).
