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TNNI3K, Active
TNNI3K, Active
- 中文名称：
- TNNI3K, Active
- 英文名称：
- TNNI3K, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74060
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human TNNI3K (300-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC117262.
The Cardiac Troponin I -interacting kinase (TNNI3K) is a serine/threonine-protein kinase, that is a member of the MAPKKK family (1). As a cardiac-specific kinase, it contains Ankyrin repeat, protein kinase, and serine-rich domains and highly expressed in the cardiomyocytes (1). Overexpression of TNNI3K has been shown to increase the progression of cardiomyopathy in mice through the Tyr and Ser/Thr kinase activity (2). The TNNI3K mutation has been involved in a familial syndrome of conduction system disease and dilated cardiomyopathy by causing the aggregation of this protein (3).
