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USP1, Active
USP1, Active
- 中文名称：
- USP1, Active
- 英文名称：
- USP1, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74094
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human full-length USP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_003368.
Ubiquitin Specific Protease 1 (USP1) is a human deubiquitinase (DUB) that contains one of the largest catalytic domains within the USP family. USP1 plays a role in regulating cellular response to DNA damage and is also involved in the control of cell differentiation (1). USP1 regulates ubiquitination of Proliferating Cell Nuclear Antigen (PCNA) in response to DNA damage preventing unscheduled recruitment of error-prone TLS DNA polymerases [2]. USP1 expression is deregulated in certain types of human cancer and is thus emerging as a novel target in cancer therapy (3).
