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USP7 (N-term), Active
USP7 (N-term), Active
- 中文名称：
- USP7 (N-term), Active
- 英文名称：
- USP7 (N-term), Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74097
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human USP7 (25-580a.a.) was expressed in E Coli cells using an N-terminal His tag. The USP7 gene accession number is NM_003470.
USP7 (ubiquitin carboxyl-terminal hydrolase 7) belongs to the peptidase C19 family and deubiquitinates FOXO4, p53, MDM2, and WASH proteins, and regulates their activities through counteracting ubiquitin ligase activity of proteins such as HDM2 and TRIM27. USP7 was found to contribute to the stabilization and trans-activation of herpesvirus 1 transcriptional protein by strongly interacting with ICP0, a regulatory protein that stimulates lytic infection and the reactivation of viral genome (1). High expression of USP7 was correlated with the proliferation, migration and invasion capacities of hepatocellular carcinoma, indicating that the enzyme may play a role in promoting tumour progression (2).
