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USP35, Active
USP35, Active
- 中文名称：
- USP35, Active
- 英文名称：
- USP35, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74108
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human USP35 (395-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The USP35 gene accession number is NM_020798.
USP35 (ubiquitin carboxyl-terminal hydrolase 35) is a member of the peptidase C19 family of ubiquitin-specific proteases that plays a role in the regulation of mitosis. USP35 deubiquitinates Aurora B, which promotes stability and activates Aurora B. The reaction also antagonizes the APCCDH1-dependent K11-linked ubiquitination of Aurora B. USP35 expression is regulated by FoxM1 as well as Aurora B in the cell cycle (1). USP35 induced by miR let-7a can inhibit cell proliferation by inhibiting NF-kappaB activation via deubiquitination and stabilization of ABIN-2 protein (2). The miR let-7a-USP35-ABIN-2 pathway can be used as a target for novel cancer therapy.
