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WNK3, Active
WNK3, Active
- 中文名称：
- WNK3, Active
- 英文名称：
- WNK3, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA74115
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human WNK3 (1-571) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_001002838.
WNK3 is a member of serine-threonine protein kinases, which was named the with-no-lysine family (1). WNK3 is expressed in several tissues including kidney and brain (1). WNK3 can regulate the activity of the electroneutral cation-coupled chloride cotransporters by activating NKCC1/2 and NCC and inhibiting KCCs (1). WNK3 kinase function is required for normal blood pressure homeostasis and the control of neuronal excitability (2). Also, overexpression of WNK3 increases the survival of Hela cells through caspase-3 pathway (3).
