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Bacillus Anthracis (Anthrax) protein (Protective Antigen)
Bacillus Anthracis (Anthrax) protein (Protective Antigen)
- 中文名称：
- Bacillus Anthracis (Anthrax) protein (Protective Antigen)
- 英文名称：
- Bacillus Anthracis (Anthrax) protein (Protective Antigen)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75323
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Shipping: Blue Ice; After receipt, store at 4°C.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Lyophilized from 10mM BIS-Tris propane, pH 8.5, with 1.25% trehalose.
Reconstitute in sterile 50% Glycerol or sterile distilled water to a final concentration of 1mg/ml. Addition of BSA may enhance stability.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
PA63 is the carboxyl-terminal 63- kDa fragment obtained by the proteolytic cleavage of the receptor-bound protective antigen (PA), one of the three proteins that comprise anthrax toxin. Unlike native PA, PA 63 oligomerizes to form a ring-shaped heptamer that binds up to three copies of EF and/or LF competitively and with high affinity (kDa ~1 nM). Whereas native PA persists on the cell surface, the heptamer is endocytosed, presumably because oligomerization aggregates anthrax toxin receptor. The endocytosed toxic complexes are trafficked to endosomal compartments where the low pH causes the PA63 heptamer to insert into the membrane and form a water-filled channel.
