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SHISA9 Antibody Positive Control
SHISA9 Antibody Positive Control
- 中文名称：
- SHISA9 Antibody Positive Control
- 英文名称：
- SHISA9 Antibody Positive Control
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75941
- 规格：
- 5 Applications|2x5 Applications|3x5 Applications|4x5 Applications|5x5 Applications
- 保存建议：
- Store at -20°C for long term storage.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Western Blot Positive Control in Ready-to-Use Buffer
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: CKAMP44/SHISA9 in SDS-PAGE sample buffer for ready-to-use application in SDS-PAGE
Relevance: Cytosine-knot AMPAR modulating protein 44 (CKAMP44A) is a novel protein that was recently identified as a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines (1). AMPA receptors (AMPARs) mediate fast synaptic transmissions in the vertebrate central nervous system (2). AMPARs are composed of four types of subunits, named as GluR1, GluR2, Glur3, and GluR4, which combine to form tetramers (3, 4). Several AMPAR-interacting proteins have been identified that affect the receptors' subcellular localization, synaptic stabilization, and kinetics, these include transmembrane AMPAR regulatory proteins (TARPs), Sol-1 and cornichons (5-7). CKAMP44A, located on human and mouse chromosome 16, was recently identified as another AMPAR-interacting protein (l). CKAMP44A was shown to modulate short-term plasticity at some excitatory synapses. ln Xenopus Oocytes, expression of CKAMP44A reduced GluR1 and GluR2 mediated steady-state currents, but it did not affect kainite or NMDA receptor-mediated currents (1).
CKAMP44A contains an extracellular N-terminal cysteine-rich motif with eight cysteines that are highly conserved across vertebrate species. Six of these eight cysteine residues might function as stabilizers for the Cys-knot structure of the CKAMP44A (l). RT-PCR analysis from various mouse tissues RNA revealed two splice variants, CKAMP44Aa and CKAMP44Ab, which differ by only 48 bases (1). This CKAMP44A-specific antibody recognizes CKAMP44Aa. Its expression is restricted to the brain; its mRNA is present in most brain structures during embryonic and postnatal development. CKAMP44Aa is approximately a 52kDa protein (432 amino acids).
