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Netrin 1 Antibody Western Blot Positive Control
Netrin 1 Antibody Western Blot Positive Control
- 中文名称：
- Netrin 1 Antibody Western Blot Positive Control
- 英文名称：
- Netrin 1 Antibody Western Blot Positive Control
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75974
- 规格：
- 5 Applications|2x5 Applications|3x5 Applications|4x5 Applications|5x5 Applications
- 保存建议：
- Store at -20 degree C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Western Blot Positive Control; Prepared in SDS-sample buffer
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Western Blot Positive Control Netrin-1 precursor Antibody
Netrins control guidance of CNS commissural axons and peripheral motor axons;serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis;Involved in tumorigenesis by regulating apoptosis.
Netrin-1 (NTRN1) also known as axonal guidance protein (NTRN1) is a diffuse protein made by the floor plate cells that belongs to the Netrirt family of proteins that guides axons to or away from the midline of the developing nervous system (1). ln mammals, netrins are ligands for DCC receptor and the UNCS receptor homologues. Netrin-'1 , located at human chromosome 17p13-p12, attracts spinal commissural axons and repels trochlear axons in vitro. ln mice, deficlencies in Netrin-1 led to defects in spinal commissural axon projections (2). ln the dorsal and intermediate spinal cord, it prevents DRG axons from being directed towards the dorsal spinal cord (3). Netrin-1 and its associated receptors play a key role cell death and tumor formation. Netrin-1/receptor pair induces apoptosis in cultured cells and also acts as regulators of tumor development (4). These properties of Netrin-1 have been implicated in colorectal tumorigenesis by regulating apoptosis (5). ln the embryo, Netrin-1 is widely exDressed in the developing nervous system and in mesodermal tissues. ln adults, it is highly expressed in heart, small intestine, colon, liver and prostrate. It is also expressed in brain tumors and neuroblastomas. Netrin-1 is approximately a 73kDa protein. The Netrinl-selective antibody (MBS540531) was generated against a peptide near C-terminal end of the Netrinl protein using cyclic peptide methodology for generating antibodies, which results in higher titer and specificity (6). MBS540531 was used to develop FITC-conjugated NTRNl-selective antibodies (MBS540531). Western blot positive control samples and antigenic blocklng peptide are available. The affinity purified mono-specific polyclonal antibody to NTRNl strongly labels a 73kDa proteln in western blot positive control (MBS543004) samples and invarious tissues examined. Antibodies can be conjugated to secondary enzymes or fluorescent probes upon request as an additional charge.
