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Phospho-MAP3K12 Antibody Positive Control
Phospho-MAP3K12 Antibody Positive Control
- 中文名称：
- Phospho-MAP3K12 Antibody Positive Control
- 英文名称：
- Phospho-MAP3K12 Antibody Positive Control
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA75982
- 规格：
- 5 Applications|2x5 Applications|3x5 Applications|4x5 Applications|5x5 Applications
- 保存建议：
- -20 degree C for long term storage
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Western Blot Positive Control
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Western Blot Positive Control Phosphorylated Mitogen-activated protein kinase kinase kinase 12 Antibody.
Overview: Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) is a MAP kinase kinase kinase enzyme belonging to the serine/threonine protein kinase family (1). Located on human chromosome 12q13, it regulates the activity of various MAPKKs such as MAPKK7 and hence activating C-Jun N-terminal Kinase (JNK/SAPK). MAP3K12 associates with scaffold proteins, JIPs, which also interacts with MAPKK7 and JNKlSAPK (2). MAP3K12 protein is associated with dotted structures that are regularly located with Golgi apparatus and also along the microtubules (3). This protein contains two leucine-zipper-like motifs and interaction of MAP3K12-binding inhibitory protein with one of these motifs deactivates this protein and induces activation of SAPK/JNK (4). MAP3K12 is also implicated in regulating radial cell migration via microtubule-based events. It has been reported that ectopic expression of this protein in neuronal precursor cells allows these cells to migrate from the ventricular zone and differentiate into neural cells (3).
MAP3K12 was identified as a signaling molecule that is required for the regulation of keratinocyte terminal differentiation and cornification (5). While MAP3K12 is found in the epidermis, it is highly restricted to the neurona. Cells in the central , peripheral and autonomic nervous systems. More specifically, it is localized in the axons of these cells (6). It has been shown that over-expression of MAP3K12 in cos-1 cells impairs the radial organization of microtubules without massive depolymerization. In humans, MAP3K12 is approximately a 68kOa protein (567 amino acids). In rat and mouse this protein weighs 107kOa (888 amino acids).
The Phospho-MAP3K12 antibodies were generated using synthetic peptide corresponding to the human PMAP3K12 protein. Western blot-positive control in ready-to-use SOS-sample buffer (PC-PMAP3K12) and antigenic blocking peptide (P-PMAP3K12) are available. Antibodies can be conjugated with fluorescent probes or other secondary enzymes upon request at extra charge.
