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Human IL-17RC Fc tagged Recombinant
Human IL-17RC Fc tagged Recombinant
- 中文名称：
- Human IL-17RC Fc tagged Recombinant
- 英文名称：
- Human IL-17RC Fc tagged Recombinant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76118
- 规格：
- 0.02 mg|0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Recombinant IL-17RC, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >98%, as determined by SDS-PAGE and HPLC
- 产品形式：
- Recombinant Interleukin-17RC is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites. Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.
