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Recombinant Human ACE2 His and DYKDDDDK Tag
Recombinant Human ACE2 His and DYKDDDDK Tag
- 中文名称：
- Recombinant Human ACE2 His and DYKDDDDK Tag
- 英文名称：
- Recombinant Human ACE2 His and DYKDDDDK Tag
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78554
- 规格：
- 0.05 mg|0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- It is shipped on ice packs. Upon arrival, store at -20 degree C. Do not freeze-thaw multiple times.
- 货期：
- 6-8周
- 纯度：
- >95% by SDS-PAGE
- 产品形式：
- 0.5mg/ml in sterile PBS with 20% Glycerol, pH 7.4
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The extracellular domain of recombinant human ACE2 (aa 20-740) is fused with C-terminus DYKDDDDK tag and His tag.
Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is the cause of COVID-19.
