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Recombinant Human TRIM29 His Tag protein
Recombinant Human TRIM29 His Tag protein
- 中文名称：
- Recombinant Human TRIM29 His Tag protein
- 英文名称：
- Recombinant Human TRIM29 His Tag protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78599
- 规格：
- 0.01 mg|0.02 mg|2x0.02 mg|3x0.02 mg|4x0.02 mg
- 保存建议：
- Recombinant Human ACE2 His Tag protein is shipped on ice packs. Upon arrival, Store at -20 degree C. Do not freeze-thaw multiple times.
- 货期：
- 6-8周
- 纯度：
- >90% by SDS-PAGE.
- 产品形式：
- PBS and 10% Glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
TRIM29 (Tripartite motif-containing 29) is a member of the tripartite motif (TRIM) family of transcription factors, characterized by the conserved RING finger, B-box, and coiled-coil domains. The TRIM family has been implicated in a variety of physiologic processes including development, apoptosis and epithelial-mesenchymal transition (EMT). Depending on a tumor types, TRIM29 also may function as an oncogene or a tumor suppressor. As an oncogene, it facilitates tumor cell proliferation and invasion through stabilization of Beta-catenin. The mechanisms may also involve deactivation of p53 activity and promoting cell survival by inhibiting proapoptotic genes regulated by p53. As a histone binding protein TRIM29 is responsible for DDR (DNA damage response). It functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DDR. TRIM29 binds to modified histone H3 and H4 tails in the context of nucleosomes. Furthermore, chromatin binding of TRIM29 is required for the phosphorylation of H2AX nucleosomes and cell viability in response to ionizing radiation.
