-
Mouse Gremlin-1
Mouse Gremlin-1
- 中文名称：
- Mouse Gremlin-1
- 英文名称：
- Mouse Gremlin-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA79272
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|5x0.05 mg|4x0.05 mg
- 保存建议：
- After initial reconstitution, store working aliquots at -20 degree C to -80 degree C. Avoid repeated freeze/thaw cycles
| Product Form | Temperature | Storage Time |
| Lyophilized | -20°C to -80°C | 1 year |
| Lyophilized | 2°C to 8°C | 6 months |
| Lyophilized | Room Temperature | 1 month |
| Reconstituted | 2°C to 8°C | 1 week |
| Extended Storage | -20°C to -80°C | 3 months |
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Sterile filtered protein solution was lyophilized from 50 mM acetic acid, free from stabilizers and preservatives
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Gremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFbeta superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80% amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFbeta superfamily ligands.
