-
Recombinant Human Heterogeneous nuclear ribonucleoprotein Q
Recombinant Human Heterogeneous nuclear ribonucleoprotein Q
- 中文名称：
- Recombinant Human Heterogeneous nuclear ribonucleoprotein Q
- 英文名称：
- Recombinant Human Heterogeneous nuclear ribonucleoprotein Q
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA81614
- 规格：
- 0.02 mg (E-Coli)|0.1 mg (E-Coli)|0.02 mg (Yeast)|0.1 mg (Yeast)|0.02 mg (Baculovirus)
- 保存建议：
- Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Liquid containing glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complentation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assbles into the GAIT complex which binds to st loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; ses not to be essential for GAIT complex function.
