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Recombinant Rat Nuclear pore complex protein Nup98-Nup96 (Nup98) , partial
Recombinant Rat Nuclear pore complex protein Nup98-Nup96 (Nup98) , partial
- 中文名称：
- Recombinant Rat Nuclear pore complex protein Nup98-Nup96 (Nup98) , partial
- 英文名称：
- Recombinant Rat Nuclear pore complex protein Nup98-Nup96 (Nup98) , partial
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA81650
- 规格：
- 0.05 mg (E-Coli)|0.05 mg (Yeast)|0.2 mg (E-Coli)|0.05 mg (Baculovirus)|0.5 mg (E-Coli)
- 保存建议：
- 在-20摄氏度下储存。对于长期储存，在-20摄氏度或-80摄氏度下储存。在4摄氏度下储存工作等分试样最多一周。不建议反复冻融。
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Lyophilized or liquid (Format to be determined during the manufacturing process)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
