DKK-1 ELISA Kit （BI-20413）
背景简介：DKK-1和
Sclerostins是wnt信号通路的有效的抑制剂，且在成骨细胞的分化过程中发挥重要作用。研究表明，骨形成减少、多发性骨髓瘤或由乳腺癌、前列腺癌、肺癌或关节炎引起的骨转移，都可导致
DKK-1水平升高。
产品优势：
- 当日即可检测
- 直接测定，不许样品稀释。
- 样本需求量少，只需：20ul
- 标准品范围广
- 充分证实可用于人血清样本检测
- 6个标准品+1个对照（均为血清基质）
- 操作流程简单
试剂盒特点：1）检测方法：夹心ELISA，HRP/TMB显色系统
2）样本类型：血清
3）样品量：20ul/test
4）标准品范围：0-160 pmol/L
5）检测灵敏度：1.7pmol/L
6）孵育条件：2h/1h/30min
参考文献：
- Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.
- Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.
- High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554.
- The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKLin Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009
- Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008
