Sclerostin （SOST） ELISA Kit ( BI-20492)
背景简介：在绝经妇女、骨固定引起的骨质流失患者、多重骨髓瘤患者
Sclerostin水平显著升高。经甲状旁腺素（PTH）和雌性激素持续治疗后，血清
Sclerostin水平降低。随着Sclerostin和DKK-1中和抗体的开发研究，有望对于骨代谢疾病治疗，获得新进展。
产品优势：
- 充分验证可用于人血清、血浆样本检测。（尿标本检测参照对应的protocol）
- 样本量小，只需20ul
- 高灵敏度-正常值介于标准曲线，标准品2和标准品3值之间。
- 6个校准品+1个对照（标准品和对照均为人血清基质，检测结果相关性更好）
- 即用型检测试剂盒
试剂盒特点：1）检测方法：夹心ELISA,HRP/TMB显色系统
2）样本类型：血清、血浆（EDTA或肝素抗凝）、尿样（参照对应的protocol）
3）样品量：20ul/test
4）标准品范围：0-240 pmol/L
5）检测灵敏度：2.6pmol/L
6）孵育条件：overnight/1h/30min（Room temperature）
7）单位转换：1pg/ml=0.044pmol
参考文献：
- Sclerostin: another bone-related protein related to all-cause mortality in haem dialysis? Viaene L et al., Nephrol Dial Transplant, 2013; 10.1093/ndt/gft039
- The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD. Pelletier S et al., Clin J Am Soc Nephrol, 2013; 8: 819-823
- Serum Sclerostin levels are associated with aortic valve calcification in prevalent ha-emodialysis patients. Türkvatan A et al., Nephrol Dial Transplant, 2013; 28: i19–i21
- Circulating Sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness. Thambiah S et al., Calcif Tissue Int, 2012; 90(6): 473-480
- Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes. Gennari L et al., J Clin Endo Metab, 2012; 97: 1737-1744
- Sclerostin and DKK-1 levels in pre-dialyisis CKD patients. Behets G et al., Nephrol Dial Transplant, 2012; 27: ii36-ii37
