欢迎您访问北京博蕾德生物科技有限公司官方网站!
服务热线:400-650-8846
一抗检测抗体
您的位置:首页 > 产品中心 > 免疫学 > 科研抗体 > 一抗
Cartilage Antibody Cocktail (Cab4)

Cartilage Antibody Cocktail (Cab4)

Cartilage Antibody Cocktail (Cab4)

报价:10000.00

联系购买
中文名称:
Cartilage Antibody Cocktail (Cab4)
英文名称:
Cartilage Antibody Cocktail (Cab4)
品牌:
Vacara
货号:
10040
规格:
1Kit
说明书:
Cartilage Antibody Cocktail (Cab4)

#10040
 
 
Immunohistochemical staining to investigate antibody binding to cartilage in vivo
Cab3 and Cab4 cocktails are pools of three and four arthritogenic antibodies, respectively, with antibodies known to bind cartilage and initiate arthritis in several mouse strains, including the commonly used C57BL/6 strain. Biotinylated versions of the antibodies may be administered in vivo, and avidin-conjugated reagents can then be used to visualize and quantify the in vivo -bound antibodies in the tissue processed ex vivo for confocal microscopy.   

The methodology to detect the cartilage-bound antibodies may be adapted to investigate the timing and fate of the arthritogenic antibodies and may be supplemented with immunohistochemical method to detect complement deposited on the cartilage. This information may be utilized to investigate the mechanisms of arthritis development in preclinical models.
References
1. Kelkka T, Hultqvist M, Nandakumar KS, Holmdahl R. Enhancement of antibody-induced arthritis via Toll-like receptor 2 stimulation is regulated by granulocyte reactive oxygen species. Am J Pathol. 2012;181(1):141–50.
2. Hagert C, Sareila O, Kelkka T, Nandakumar KS, Collin M, Xu B, Guérard S, Bäcklund J, Jalkanen S, Holmdahl R. Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells: A Novel Experimental Model of Rheumatoid Arthritis. Arthritis Rheumatol. 2018 Aug;70(8):1343-1353.
3. Li Y, Tong D, Liang P, Lönnblom E, Viljanen J, Xu B, Nandakumar KS and Holmdahl R. Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis. Arthritis Research & Therapy (2020) 22:120. (Link to the Creative Commons Licence: http://creativecommons.org/licenses/by/4.0/)
4. Kagari T, Tanaka D, Doi H, Shimozato T. Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis. J Immunol. 2003;170(8):4318–24.
5. Holers VM, Banda NK. Complement in the Initiation and Evolution of Rheumatoid Arthritis. Front Immunol. 2018; 9: 1057.
6. Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. 2017 Jul 6; 2(13): e93688.
 

快速响应

即时响应 客户需求

正品保障

正品行货 值得信赖

急速物流

发货迅速 快速物流

退还承诺

退换保障 品质无忧

正规发票

发票保障 售后无忧

在线咨询
在线咨询
QQ交谈
微信咨询
微信咨询