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Vacara是一家瑞典公司,致力于开发新型类风湿性关节炎诊断试剂盒、创新的预防和治疗方法。产品包括:诊断试剂盒、疫苗研究产品、保护性抗体以及人源化动物模型和用于诱导设计的免疫反应和诱导T细胞介导的关节炎的抗原(Cag1、Cag2、Cag3、Cag4、Cag5)。
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Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)
Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)
10020 次关注
价格:¥3000.00
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中文名称: Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP) 品牌: Vacara
英文名称: Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP) 货号: 10020
规格: 100ug 说明书:
货期: 4周 保存温度: -20℃
运输温度: 2-8℃    

Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)

#10020


     Genetically modified mouse strains have most often been developed on the C57BL/6 genetic background, which has restricted their use for rheumatology research due to the lack of reliable model for rheumatoid arthritis (RA) for this strain. The C57BL/6 mice possess the MHC class II haplotype H‑2b, which has so far prohibited induction of any known model for rheumatoid arthritis.

      Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis is a new model for rheumatoid arthritis in the C57BL/6 mouse. It is established by immunization by native COMP and leads to severe arthritis with characteristic T and B cell responses against defined COMP peptides.

COMP induced arthritis provides disease model to study the immune priming, the effector and chronic phases of arthritis and can be used for efficient induction of arthritis in the C57BL/6J mice.

       The key for successful arthritis experiments to solve your research questions is a thorough understanding of the model with its advantages and limitations.
References
1. Holmdahl R, Andersson M, Goldschmidt TJ, Gustafsson K, Jansson L, Mo JA. Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990;118:193-232.
2. Bäcklund J, Li C, Jansson E, Carlsen S, Merky P, Nandakumar KS, et al. C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann Rheum Dis. 2013;72(7):1225-32.
3. Zhao Y, Urbonaviciute V, Xu B, Cai W, Sener Z, Ge C, et al. Cartilage Oligomeric Matrix Protein Induced Arthritis-A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse. Front Immunol. 2021;12:631249.
4. Holmdahl R, Carlsen S, Mikulowska A, Vestberg M, Brunsberg U, Hansson A-S, et al. Genetic analysis of murine models for rheumatoid arthritis. In: Adolpho KW, editor. Human Genome Methods. New York: CRC press; 1998. p. 215-38.
5. Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012;14(4):R191.
6. Malmström V, Michaëlsson E, Burkhardt H, Mattsson R, Vuorio E, Holmdahl R. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis. Proc Natl Acad Sci U S A. 1996;93(9):4480-5.
7. Hultqvist M, Bäcklund J, Bauer K, Gelderman KA, Holmdahl R. Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice. J Immunol. 2007;179(3):1431-7.
8. Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, et al. Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum. 2008;58(7):2000-11.
9. Carlsén S, Hansson AS, Olsson H, Heinegård D, Holmdahl R. Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin Exp Immunol. 1998;114(3):477-84

      Vacara是一家瑞典公司,致力于开发新型类风湿性关节炎诊断试剂盒、创新的预防和治疗方法。产品包括:诊断试剂盒、疫苗研究产品、保护性抗体以及人源化动物模型和用于诱导设计的免疫反应和诱导T细胞介导的关节炎的抗原(Cag1、Cag2、Cag3、Cag4、Cag5)。
   产品信息:
品牌 货号 产品名称 规格
Vacara 10110 Mouse Anti col2A1 Antibody (M2139) 100µg/0.1mL 
Vacara 10130 Mouse Anti citrullinated COL2A1 Antibody (ACC1) 100µg/0.1mL  
Vacara 10120 Mouse Anti Collagen XI Antibody (L10D9) 100µg/0.1mL 
Vacara 10150 Mouse Anti Cartilage Oligomeric Matrix Protein Antibody (16B5) 100µg /0.1mL 
Vacara 10030 Cartilage Antibody Cocktail (Cab3) 100µg /0.1mL 
Vacara 10040 Cartilage Antibody Cocktail (Cab4) 100µg /0.1mL 
Vacara 10020 Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP) 100ug
Vacara 10140 Mouse Anti- Cartilage Oligomeric Matrix Protein Antibody (15A11) 100µg/0.1mL 

更多产品订购,请联系Vacara中国区总代理北京博蕾德生物科技有限公司
 

 
品牌 货号 产品名称 规格 货期 单价 操作
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Vacara 10030 Cartilage Antibody Cocktail (Cab3) 1Kit 4周 ¥10000.00 详情
Vacara 10150 Mouse Anti- Cartilage Oligomeric Matrix Protein Antibody (16B5) 100µg /0.1mL 4周 ¥2500.00 详情
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