-
Anti-Alpha Synuclein Antibody
Anti-Alpha Synuclein Antibody
- 中文名称：
- Anti-Alpha Synuclein Antibody
- 英文名称：
- Anti-Alpha Synuclein Antibody
- 品牌：
- Antibodies Inc
- 品牌介绍：
- Antibodies Inc.成立于1962年， 在神经科学领域备受推崇，拥有针对关键神经科学靶点的一流小鼠单克隆抗体。最初专注于二抗和免疫测定，在2005年，与加州大学戴维斯分校和美国国立卫生研究院合作，成为高度验证的NeuroMab系列小鼠单克隆抗体的商业供应商。这些高品质的抗体经过全部测试，数十种已进行基因敲除验证，并提供四种不同荧光标记物的抗体。我们的定制抗体服务提供量身定制的解决方案，包括单克隆和多克隆选项，以及生产、共轭和免疫测定服务。所有这些工作都在位于加利福尼亚州戴维斯的ISO-13485认证设施中完成。
- 货号：
- 77-521
- 规格：
- 100 µL
- 保存建议：
- 分装后于 ≤ -20°C 长期储存；短期储存可保存于 2–8°C。为最大限度回收产品，请在打开瓶盖前先离心试剂瓶。
- 背景资料：
- Alpha-synuclein (SNCA), also known as PARK1, NACP, PARK4, is a member of the synuclein family, which also includes beta- and gamma-synuclein. Alpha-synuclein is a highly conserved protein known to be abundant in neurons and especially presynaptic terminals where it serves multiple roles including regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Functionally, alpha-synuclein has been implicated in synaptic plasticity (Liu 2004) and the assembly of snare complexes (Burre 2010) and it is known to be associated with various neuropathologies including Parkinson's Disease, Lewy Body Dementia, and Alzheimer's Disease, where it forms insoluble protein aggregates. Early studies of amyloid deposits in the brains of Alzheimer's patients revealed two previously uncharacterized peptides in addition to the amyloid beta fragment (Ueda 1993), both of which were found to correspond to alpha-synuclein (SNCA). Later studies confirmed that aggregated alpha-synuclein proteins are present in brain lesions (Lewy bodies) that are hallmarks of neurodegenerative synucleinopathies and that alpha-synuclein likely plays a role in the pathogenesis of Parkinson's disease, Lewy body dementia, and Alzheimer’s disease among other neuropathologies. The SNCA antibody was raised against full-length human alpha-synuclein and recognizes endogenous levels of alpha-synuclein in brain by Western blot and immunohistochemistry.
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Non-Human Primate, and Rat
- 应用：
- WB, IHC, ICC, ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
免疫原物种：Human
克隆性：Monoclonal
克隆号：6113-62
浓度：1 mg/mL
分子量：18 kDa
- 说明书：
Our Anti-Alpha-Synuclein mouse monoclonal primary antibody from Antibodies Incorporated is produced in-house from hybridoma clone 6113-62. It is KO validated, detects human, mouse, non-human primate, and rat Alpha-Synuclein, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.
