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Anti-Alpha Synuclein Antibody
Anti-Alpha Synuclein Antibody
- 中文名称：
- Anti-Alpha Synuclein Antibody
- 英文名称：
- Anti-Alpha Synuclein Antibody
- 品牌：
- NeuroMab
- 品牌介绍：
- NeuroMab是美国国立卫生研究院神经单抗研究所成立于2004年，旨在生产可用于神经学研究的小鼠单克隆抗体。这些抗体广泛应用于动物脑组织样本检测，包括免疫印迹、免疫组化等。引用NeuroMab的产品发表的文献，已超过：3300篇。
- 货号：
- 77-521-020
- 规格：
- 20 µL
- 保存建议：
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
- 背景资料：
- Alpha-synuclein (SNCA), also known as PARK1, NACP, PARK4, is a member of the synuclein family, which also includes beta- and gamma-synuclein. Alpha-synuclein is a highly conserved protein known to be abundant in neurons and especially presynaptic terminals where it serves multiple roles including regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Functionally, alpha-synuclein has been implicated in synaptic plasticity (Liu 2004) and the assembly of snare complexes (Burre 2010) and it is known to be associated with various neuropathologies including Parkinson's Disease, Lewy Body Dementia, and Alzheimer's Disease, where it forms insoluble protein aggregates. Early studies of amyloid deposits in the brains of Alzheimer's patients revealed two previously uncharacterized peptides in addition to the amyloid beta fragment (Ueda 1993), both of which were found to correspond to alpha-synuclein (SNCA). Later studies confirmed that aggregated alpha-synuclein proteins are present in brain lesions (Lewy bodies) that are hallmarks of neurodegenerative synucleinopathies and that alpha-synuclein likely plays a role in the pathogenesis of Parkinson's disease, Lewy body dementia, and Alzheimer’s disease among other neuropathologies. The SNCA antibody was raised against full-length human alpha-synuclein and recognizes endogenous levels of alpha-synuclein in brain by Western blot and immunohistochemistry.
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, Non-Human Primate, and Rat
- 应用：
- WB, IHC, ICC, ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
浓度:1 mg/mL
推荐稀释比（WB）:1:200-1:500
推荐稀释比（WB Brain）:1:200-1:500
推荐稀释比（IHC）:1:5000
推荐稀释比（ICC）:1:1000
- 说明书：
Our Anti-Alpha-Synuclein mouse monoclonal primary antibody from Antibodies Incorporated is produced in-house from hybridoma clone 6113-62. It detects human, mouse, non-human primate, and rat Alpha-Synuclein, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
