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Anti-SARM1 Antibody FL490 Conjugate
Anti-SARM1 Antibody FL490 Conjugate
- 中文名称：
- Anti-SARM1 Antibody FL490 Conjugate
- 英文名称：
- Anti-SARM1 Antibody FL490 Conjugate
- 品牌：
- Antibodies Inc
- 品牌介绍：
- Antibodies Inc.成立于1962年， 在神经科学领域备受推崇，拥有针对关键神经科学靶点的一流小鼠单克隆抗体。最初专注于二抗和免疫测定，在2005年，与加州大学戴维斯分校和美国国立卫生研究院合作，成为高度验证的NeuroMab系列小鼠单克隆抗体的商业供应商。这些高品质的抗体经过全部测试，数十种已进行基因敲除验证，并提供四种不同荧光标记物的抗体。我们的定制抗体服务提供量身定制的解决方案，包括单克隆和多克隆选项，以及生产、共轭和免疫测定服务。所有这些工作都在位于加利福尼亚州戴维斯的ISO-13485认证设施中完成。
- 货号：
- 77-522-FL490
- 规格：
- 200 µL
- 保存建议：
- 分装后于 ≤ -20°C 长期储存；短期储存可保存于 2–8°C。为最大限度回收产品，请在打开瓶盖前先离心试剂瓶。
- 背景资料：
- SARM1 ( Sterile Alpha and TIR Motif-Containing 1) is predominantly expressed in the nervous system, particularly in neurons, and is highly conserved across different species. It encodes a protein that contains several functional domains, including a sterile alpha motif (SAM) domain, a Toll/interleukin-1 receptor (TIR) domain, and a catalytic domain with NAD^+ hydrolase activity.SARM1 activation triggers a cascade of molecular events that leads to the breakdown of axonal structures and eventual degeneration. In response to injury, SARM1 is activated and catalyzes cleavage of NAD+ into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide. In the nervous system, NAD+ depletion is a critical step in the axonal degeneration process, known as Wallerian degeneration, and is essential for clearing damaged axons to allow for regeneration and repair. Inhibition of SARM1 or the preservation of NAD+ levels has been shown to protect axons from degeneration in experimental models, suggesting SARM1 as a potential therapeutic target for neurodegenerative diseases and nerve injuries.Research on SARM1 has primarily focused on its role in axonal degeneration and neuroprotection. Understanding the molecular mechanisms underlying SARM1 activation and its downstream effects may have implications for developing treatments for various neurological disorders, such as peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases like Parkinson's and Alzheimer's.
- 货期：
- 4-6周
- 来源宿主：
- Mouse
- 反应种属：
- Human, Mouse, and Rat
- 应用：
- IHC, ICC
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
免疫原物种：Human
克隆性：Monoclonal
克隆号：1561353
浓度：0.5 mg/mL
分子量：73 kDa
- 说明书：
Our Anti-SARM1 mouse monoclonal primary antibody from Antibodies Incorporated is produced in-house from hybridoma clone 1561353. It detects human, mouse, and rat SARM1, and is purified by protein a chromatography. It is great for use in IHC, ICC.
